Abstract

SOME ADVERSE EFFECTS OF FOSFOMYCIN IN RATS

M.G.A. El. Sayed, Amany.El.Mleeh and Heba. Mohamed*

ABSTRACT

The aim of this study was to determine the adverse effects of fosfomycin on liver, kidney functions which was evaluated by measuring liver and kidney enzymes and through histopathological examination of liver and kidney tissues. Sixty six male Wister albino rats were randomly divided into main six groups including Group(1): control (saline only 0.2ml) Group(2): fosfomycin was given orally 300 mg/kg body weight for 5 days; Group(3), vancomycin was administrated intraperitoneally 200 mg/kg body weight daily for 7 days; Group(4), fosfomycin as in group 2 followed by intraperitoneal injection of vancomycin 200 mg/kg body weight for 7 days; Group(5), Nigella sativa oil was given orally 1 ml/kg for 10 days and Group (6), Nigella sativa oil as group 5 followed by fosfomycin orally 300 mg/kg body weight for 5 days. The finding revealed that there was significant increase in liver enzymes of rat given fosfomycin treatment group. There was significant decrease in liver enzymes of fosfomycin with Nigella sativa group and improvement of histopathological study compared to fosfomycin. There was no significant change in kidney enzymes of fosfomycin treated group. There was decrease in kidney enzymes of fosfomycin with vanomycin group compared to vancomycin group.

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