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Abstract

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF SOME NOVEL SUBSTITUTED 3-PROPYLBENZO[D]THIAZOL-2(3H)-ONES AND 3-PROPYLBENZO[D]OXAZOL-2(3H)-ONES FOR THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES

Sowjanya M.*, Vishwanath B. A. and Kumudha D.

ABSTRACT

A series of some novel benzo[d]thiazole-2(3H)ones (7aA-7aD) and benzo[d]oxazole-2(3H)ones (7bA-7bD) were synthesized and evaluated for antibacterial and antifungal activities. In the present work the thiazole and oxazole ring structures were synthesized by reacting with ortho thiophenol or ortho aminophenol with urea to yield benzo[d]thiazol-2(3H)-one (3a) or benzo[d]oxazol-2(3H)-one (3b) respectively. The then formed compounds 3a and 3b are alkylated using dibromopropane to yield 3-(3-bromopropyl)benzo[d]thiazol-2(3H)-one (5a) and 3-(3-bromopropyl)benzo[d]oxazol-2(3H)-one (5b). Titled compounds are synthesized by reacting 5a and 5b with various secondary amines (A-D) in presence of K2CO3 to yield 7aA-7aD and 7bA-7bD.

Keywords: Benzthiazole, Benzoxazole, Antibacterial, Antifungal.


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