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*Hemalatha Sattu and Perla Swathi


A series of novel heterocyclic derivatives were prepared by acetylation of Imidazole (1) and Acetyl chloride (2) to give respective N-acetyl imidazole (3),which was further reacted with different substituted aromatic aldehydes (4) in the presence of (Aldol Condensation) Ethanol and NaOH used as base to give Imidazolo Chalcone derivatives (5). All the synthesized compounds are confirmed by physicochemical data by using various Softwares like Molinspiration, Molsoft, OSIRIS and spectral analysis of 1H NMR, IR and MASS spectra. All the compounds are screened for antibacterial, antifungal and antioxidant activity. The antibacterial activity (Oflaxacin 100μg/ml) against B.Subtilis and The antifungal activity (Greseofulvin 100μg/ml) against pencillinium chrysogenum were determined by cup plate method. Anti oxidant activity is determined by stable free radical method, ascorbic acid is used as the standard. All the compounds showed good pharmacokinetic and pharmacodynamic properties. Among all the compounds 5a,5b (10 and 30 μg/ml) and 5c (200μg/ml) showed potent antibacterial and antifungal activity, All the synthesized compounds showed potent antioxidant activity.

Keywords: Acetylation, Aromatic aldehydes, Aldol condensation and Imidazolo Chalcone derivatives.

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