WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF IMIDAZOLO-CHALCONE DERIVATIVES

*Hemalatha Sattu and Perla Swathi

ABSTRACT

A series of novel heterocyclic derivatives were prepared by acetylation of Imidazole (1) and Acetyl chloride (2) to give respective N-acetyl imidazole (3),which was further reacted with different substituted aromatic aldehydes (4) in the presence of (Aldol Condensation) Ethanol and NaOH used as base to give Imidazolo Chalcone derivatives (5). All the synthesized compounds are confirmed by physicochemical data by using various Softwares like Molinspiration, Molsoft, OSIRIS and spectral analysis of 1H NMR, IR and MASS spectra. All the compounds are screened for antibacterial, antifungal and antioxidant activity. The antibacterial activity (Oflaxacin 100μg/ml) against B.Subtilis and The antifungal activity (Greseofulvin 100μg/ml) against pencillinium chrysogenum were determined by cup plate method. Anti oxidant activity is determined by stable free radical method, ascorbic acid is used as the standard. All the compounds showed good pharmacokinetic and pharmacodynamic properties. Among all the compounds 5a,5b (10 and 30 μg/ml) and 5c (200μg/ml) showed potent antibacterial and antifungal activity, All the synthesized compounds showed potent antioxidant activity.

Keywords: Acetylation, Aromatic aldehydes, Aldol condensation and Imidazolo Chalcone derivatives.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More