WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

CHOLESTEROLEMIC AND ANTIOXIDANT EFFECTS OF EXTRACTS OF SOME LOCALLY CONSUMED FRUITS IN MAIDUGURI

Uju Nwezoku*, Prof. M. A. Milala and Prof. A. A. Gidado

ABSTRACT

The study assessed the in vitro antioxidant potential of Cucumis sativus, Solanum macrocarpon and Solanum aethiopicum and cholesterolemic effect of Solanum macrocarpon ethanolic extract in in vivo models. The antioxidant activity of the fruit was determined by the DPPH radical scavenging method. CCl4 was used to induce hepatotoxicity, catalase and superoxide dismutase was used to study the antioxidant potential of the ethanolic extract of Solanum macrocarpon. Lipid profile- HDL, LDL, TGs, VLDL and Cholesterol were used to study the effect of the ethanolic extract of Solanum macrocarpon on the lipid panel during hepatotoxicity. The in vitro antioxidant screening showed Cucumis sativus, Solanum macrocarpon and Solanum aethiopicum all had antioxidant activities but Solanum macrocarpon had the highest antioxidant activity (286.52% RSA), and this, informed its use for further in vivo antioxidant and Lipid profile studies. CCl4 treated groups had significantly elevated concentrations of LDL 0.80mmol/l and significantly decreased concentration of cholesterol 1.76mmol/l. The extract fed groups showed significant decrease in HDL and cholesterol concentrations respectively (HDL-1.74mmol/l, Chol-1.73mmol/l and 1.46mmol/l). CCl4 had no significant effect on the antioxidant enzymes. Thus, Solanum macrocarpon may be said to possess plasma lipid lowering potential whose mechanism may not be associated with free radical scavenging.

Keywords: .


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More