Abstract

A REVIEW ON RENAL PROTECTIVE AGENTS FOR CYCLOPHOSPHAMIDE INDUCED NEPHROTOXICITY

Monika Singh*, Nikhlesh Kumar, Mohd. Shuaib, Vipin Kumar Garg, AnjanaSharma.

ABSTRACT

The most common limitation of cancer chemotherapy is the multiple organ toxicity and injury of normal tissue. Cyclophosphamide, which is most widely used alkylating agent, is associated with induction of tubular necrosis, tubular fibrosis, glomerular congestion and inflammation, which ultimately causes renal dysfunction. A little information is available about the pathogenic mechanism of cyclophosphamide induced renal damage. Oxidative stress may be involved in causing cyclophosphamide induced renal damage because its active metabolites form reactive oxygen species.

Keywords: Cyclophosphamide, Nephrotoxicity, Antioxidants, Free radicals.