Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS JUNE ISSUE PUBLISHED
  • JUNE 2020 Issue has been successfully launched on 1 June 2020.

Abstract

FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF ANTIHYPERTENSIVE DRUG

*Uday Mahajan, Bharat Parashar

Department of Pharmaceutics, Manav Bharti University, Solan, Himachal Pradesh, India.

ABSTRACT

The present investigation deals with the formulation of taste masked fast disintegrating tablets of Antihypertensive drug that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Antihypertensive drug is a drug that is primarily used in the treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complication of diabetes that acts by inhibiting angiotensin converting enzyme (ACE). The influence of superdisintegrants such as polyplasdone xl-10, croscaremellose sodium and sodium starch glycolate on disintegration time, wetting time and water absorption ratio were studied. Tablets were evaluated for weight and thickness variation, disintegration time, drug content, in vitro dissolution, wetting time and water absorption ratio. The in vitro disintegration time of the best fast disintegrating tablets was found to be within 32 seconds. Tablets containing polypasdone xl-10 exhibit quick disintegration time than tablets containing croscaremellose sodium and sodium starch glycolate. The fast disintegrating tablets of Antihypertensive drug with shorter disintegration time, acceptable taste and sufficient hardness could be prepared using crospovidone and other excipients at optimum concentration.

Keywords: polyplasdone xl-10, Sodium Starch Glycolate, crosscarmellose sodium, fast disintegrating tablet, Antihypertensive drug, Superdisintigrants.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More