Abstract

BIOCHEMICAL STUDY ON THE REGENERATIVE EFFECT OF CHROMIUM PICOLINATE ON EXPERIMENTALLY INDUCED DIABETES

Yakout A. El Senosi*, Omayma, A. R. Abou Zaid, Afaf Desouky A. Elmaged, Mohamed A. M. Ali*

ABSTRACT

In the present study, the potential therapeutic effect of Chromium picolinate administration diabetic rats was evaluated. Thirty male albino rats were divided into three equal groups of 10 rats each. Group Ι :( Control group): received no drugs. Group II :( Diabetic rats group): rats received a single dose of Streptozotocin (STZ) (50- mg/kg-b.wt i.p). Group III :( Diabetic rats + Chromium picolinate treated group): rats are treated with + Chromium picolinate 8.8 mg /kg body weight /day, orally) for 21 days after diabetes induction. Blood samples and pancreatic tissue were collected at the 22th day from the onset of + Chromium picolinate administration. The obtained results showed that, STZ-induced diabetic rats exhibited a significant increase in serum glucose, triacylglycerols, total cholesterol, LDL-cholesterol, malondialdehyde (MDA), advanced glycation end products (AGEs) and glycated hemoglobin (HbA1c) with marked decrease in HDL-cholesterol, insulin levels, Catalase (CAT), glutathione peroxidase (GSH-px), superoxide dismutase (SOD). Treatment with chromium picolinate was able to mitigate diabetic abnormalities through decreasing serum glucose, triacylglycerols, total cholesterol, LDL-cholesterol, malondialdehyde (MDA), advanced glycation end products (AGEs) and glycated hemoglobin (HbA1c) and increasing HDL-cholesterol, insulin levels, Catalase (CAT), glutathione peroxidase (GSH-px) and superoxide dismutase (SOD), These results suggest that chromium picolinate are effective in increasing insulin sensitivity and secretion in diabetic rats and improving other biochemical blood parameters.

Keywords: chromium picolinate; STZ; Diabetes; lipid profil; Antioxidant enzymes; AGEs and HBA1c.