Abstract

ANTIDIABETIC AND HYPOLIPIDEMIC EFFECT OF ASPARAGUS RACEMOSUS IN ALLOXAN INDUCED DIABETES IN RATS

Wesam E.M., Yakout A.El-Senosi, Samy A. Aziza, and Souad A. Ahmad.

ABSTRACT

The Asparagus racemosus was evaluated for its antidiabetic activities and hypolipidemic activity against alloxan induced hyperglycemia in rats. Thirty rats were used divided into 2 groups, normal control: Composed from 10 rats and diabetic group composed from 20 rats I.P. injection. of alloxan by dose 120mgm/kg b. w, This group subdivided into 2 subgroup: Alloxan group: 10 rats as control negative. Asparagus treated group: 10 rats administrated Asparagus racemosus powder by dose 500 mg/kg b. Wt. daily P.O. for 30days. (Kumar et al., 2011and Sara et al., 2013) Diabetes is recognized as a group of heterogeneous disorders with the common of hyperglycaemia and glucose intolerance, due to insulin deficiency, impaired of insulin action, or both (Harris and Zimmet, 1997). Diabetes mellitus type 1 is caused by insufficient or non-existent production of insulin, while type 2 is primarily due to a decreased response to insulin in the tissues of the body which called insulin resistance. Both types of diabetes, if untreated, result in too much glucose remaining in the blood which defined as hyperglycemia and many of the same complications. Also, too much insulin and/or exercise without enough corresponding food intake in diabetics can result in low blood sugar which named as hypoglycemia (Hsu et al., 2007). Daily administration of Asparagus racemosus to diabetic rats by dose (500 mg/kg b. wt.) for 30 days decreased serum glucose. These findings indicate that anti hyperglycemic activity of Asparagus racemosus mediated by inhibition of carbohydrate digestion and

Keywords: absorption, together with enhancement of insulin secretion and action in the peripheral tissue (Hannan, et al., 2011).