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  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

FORMULATION AND EVALUATION OF TERBUTALINE SULPHATE PULSATILE DRUG DELIVERY SYSTEM

Nandvishal V. Deore*, Vinod M. Thakare, Bharat W. Tekade, Vijay R. Patil.

TVESís H.L.M.C. College of Pharmacy, Faizpur- 425503, Tal. Yawal Dist. Jalgaon, Maharashtra, India.

ABSTRACT

Present research work was planned to developed a novel dosage form using a chronopharmaceutical approach. A pulsatile dosage form, taken at bedtime with a programmed start of drug release can prevent a sharp increase in the incidence of asthmatic attacks, during the early morning hours. The powedr blend was evaluated for pre compression parameters. The pulsatile formulation was prepared by direct compression method by using different concentrations of guar gum. After that ten batches are selected and coated with enteric coated polymer shellac. Prepared tablets were evaluated for post compression parameters. Tablets were subjected to in-vitro drug release study in 1.2 pH and 7.4 pH. The formulation F8 shows significant behaviour pattern compared with other formulations.

Keywords: Terbutaline sulphate; Colon Delivery System; shellac.


[Full Text Article]

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