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Abstract

REVIEW OF TOPICAL PAIN KILLER GEL

*Priya munshi, D.S.Mohale, A. V. Chandewar

Department of Quality assurance, P. Wadhwani College of Pharmacy, Yavatmal - 445001. India.

ABSTRACT

It is phynyl acitic acid derivative developed as anti-inflammatory agent. It has nalgesic anti-inflammatory antipyretic like actions like other NSAIDS. It is recommended in long term treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is also useful acute mescuskelatal disorder post operative pain and dysmenorrhoea Diclofenac sodium gel were developed in different formulations to by employing different grades of polymers such as Hpmck4m and Crbopol940. There the various Diclofenac gels are available in market.but the propose gel is formulated with two key ingredients oleoresin, andl linseed oil contribute to anti-inflammatory effect. The formulations were evaluated for various physical parameters, ph spredibility, drug relese excrutability studies drug released mechanisms.formulation showed maximum drug releaseof hours and maximum drug. Finally the gel formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.

Keywords: Diclofenac sodium, Topical Gel, Pain killer.


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