Abstract

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG TINIDAZOLE BY SOLID DISPERSION TECHNIQUE

Yamini B. Patil*, Dr. Sunila T. Patil and Dr. Sunil P. Pawar

ABSTRACT

Tinidazole is nitro imidazole derivative, anti-parasitic drug against protozoan infection. It is used as tissue amoebic ides for both intestinal and extra intestinal amoebiasis. It has broad spectrum cidal activity against protozoa including giardia lamblia many anaerobic bacteria such as fragilis, fusobacterium, clostridium perfrigens, and helicobacter pylori. But as it is BCS class–II Drug, Dissolution from its dosage form is too low and rate limiting step in absorption of drug. The present study was aimed to increase the solubility of the poorly water soluble drug (Tinidazole) by using hydrophilic polymers (PEG 6000 and Mannitol). Solid dispersions were prepared by hot melt method. Phase solubility study, in-vitro dissolution of pure drug, physical mixtures and solid dispersions were carried out. PEG and Mannitol were found to be effective in increasing the dissolution of Tinidazole in solid dispersions when compared to pure drug. FT-IR spectroscopy studies were carried out in order to characterize the drug and solid dispersion.

Keywords: Solid dispersion, Bioavailability, PEG 6000, Mannitol, Hot melt method.