Abstract

FORMULATION AND EVALUATION OF LIPOSOMES OF TRAMADOL HYDROCHLORIDE

Divya Kanungo*, Sunita Patidar, Deepak sen and Nutan Mimrot, Revathi A. Gupta

ABSTRACT

Controlled drug release methods such as the utilization of liposomal or biodegradable polymer microencapsulation are technique used for increasing the duration of action and decreasing the toxicity of drug. Analgesic drug, Tramadol Hydrochloride was encapsulated in liposomes for topical application. Tramadol liposomes were prepared by Modified “Ether Injection” method was used. In the formulation two different surfactant and two different lipids are used in different combinations. The prepared liposomes were characterized for size, shape, entrapment efficiency, in-vitro drug release (by franz diffusion cell). The studies demonstrated successful preparation of Tramadol Hydrochloride liposomes and effect of soya lecithin: cholesterol weight ratio on entrapment efficiency and on drug release.

Keywords: Anangesic, Liposomes, Tramadol, Soya lecithin, Cholesterol.