Abstract

NANO-LIPID CARRIERS: A FORMIDABLE DRUG DELIVERY SYSTEM

Subharaj Saha*, Nagasamy Venkatesh D. and Annesha Deb

ABSTRACT

Lipid nanoparticles (LNPs) have attracted special interest during the last few decades. Nano lipid carriers (NLCs) are one of the major types of lipid-based nanoparticles. Nano lipid carriers (NLCs) are drug-delivery systems comprises of both solid and liquid lipids as the core matrix. It was seen that NLCs reveal some merits for drug therapy over the conventional carriers, including enhancing solubility, the ability to increase storage stability, improved permeability and bioavailability, decreased adverse effect, prolonged half-life, and tissue-targeted delivery. NLCs have attracted increasing attention in recent years. This review illustrates recent developments in drug delivery arena using NLCs strategies. The structural features, preparation techniques and physicochemical characterization of NLCs are systematically explained in this review. The next generation lipid nanoparticle i.e. NLCs are modified SLNs which improve the stability and loading capacity. Three structural models of NLCs have been proposed. These LNPs have enormous applications in drug delivery field, research, cosmetics, clinical medicine, etc.

Keywords: LNPs, SLNs, increased solubility, SLNs, stability.