Abstract

HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF AERIAL PARTS OF PIPER TRIOICUM ROXB AGAINST CCL4 INDUCED LIVER DAMAGE IN RATS

Aparna Lakshmi I.*, M. Gobinath, Joyeeta Bhattacharya and Priyanka P.

ABSTRACT

The hepatoprotective activity of ethanolic extract of aerial parts of Piper trioicum Roxb (EEPT) against carbon tetrachloride (CCl4) induced liver damage is reported in albino rats. There was a marked elevation of serum marker enzyme levels and lipid peroxidation in CCl4 treated rats, which were restored towards normalization in the extract (EEPT 100 mg/kg and 200 mg/kg body weight intraperitoneally (i.p), once daily for 14 days) treated animals. The levels of antioxidant enzymes like Superoxide dismutase (SOD), Catalase and Glutathione peroxidase (GPx) were markedly decreased in CCl4 treated rats which were increased and brought back to normal level in the treated animals. The results indicated that the EEPT at a dose of 200 mg/kg might prove to be a potent hepatoprotective agent.

Keywords: Piper trioicum, antioxidant, in vitro, reducing power.