Abstract

ANTI-HYPERTENSIVE DRUGS ADVERSE DRUG REACTIONS AND ITS MANAGEMENT

Masrath Fathima* and Zainab Mahveen

ABSTRACT

According to the World Health Organization (WHO) definition, an adverse drug reaction (ADR) is ‗a response to a drug that is noxious and unintended and occurs at doses normally used in human for the prophylaxis, diagnosis, and treatment of disease, or for modification of physiological function. Hypertension is a chronic disease condition which is considered to be one of the major cardiovascular risk factor. Antihypertensive drugs are frequently associated with adverse drug reactions (ADRs) that may limit treatment options and reduce patient adherence, which may hinder blood pressure control. Hypertensive patients often have concomitant disease condition such as hyperlipidaemia, impaired glucose metabolism and renal impairment, leading to an increased rate of Cardio Vascular morbidity and mortality. Therefore, a comprehensive management of both hypertension as well as concomitant Cardio Vascular Disease risk factors is critical when treating hypertensive patients. For the treatment of hypertension a wide range of anti-hypertensive agents are available as single or combination therapy to achieve a target blood pressure in individual patient.

Keywords: Introduction of hypertension, treatment of hypertension, Adverse drug reactionand its management, discussion, conclusion, reference.