Abstract

EFFECT OF SERUM BIOCHEMICAL MARKERS AND HAEMATOLOGICAL VALUES IN SUB-ACUTE TOXICITY STUDY OF CISSUS QUADRANGULARIS (STEM)

*S.Shamina¹, Gokilavani²

¹Dept of Biochemistry, RVSCAS, Tamilnadu, India
²Dept of Biochemistry Kongunadu college, Tamilnadu, India

ABSTRACT

Cissus quadrangularis is a traditional medicinal plant that is commonly used for bone disorders. Cissus quadrangularis (CQ) a climber of vitaceae family, is known as “Phet-Cha-Sung-Khaat in Thai. The stout fleshy quadrangular stem of CQ is used for treatments of various conditions such as hemorrhoid, irregular menstruation and also acceleration of bone fracture healing. The study reports the toxicological studies of aqueous extract of Cissus quadrangularis in female albino rats. The results indicated that the acute doses of the extract caused significant changes in AST and ALT. While the increase in ALT and AST in animals was dose dependent as the values obtained for the animals at the highest dose of the extract was not significantly different to the control It also showed no significant difference at the dose level of 250mg/ kg/day comparing to the control rats. The results confirmed shows that that there is no significant difference in the body weights at the dose of 250mg/kg/day.

Keywords: Cissus quadrangularis, AST, ALT.