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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

SYNTHESIS, EVALUATION AND ANTIMICROBIAL ACTIVITY OF BENZOXAZOLE DERIVATIVES

*Deepak Shrivastava

Indore Institute of Pharmacy (IIP) Indore Rau-Pithampur Road Indore (M.P.) INDIA.

ABSTRACT

New 5methyl substituted phenol benzoxazoles derivatives were synthesized by the reaction of 5-methyl 2- amino phenol with various aldehydes in the presence of ethyl alcohol and lead tetra acetate. All the compounds were characterized by their analytical and spectral (IR, 1HNMR and Mass) data. Synthesized compounds have been evaluated for their antimicrobial (gram +ve and gram –ve) and antifungal activities (C. Albicans) by standard method at 50μg/ml and 100μg/ml concentration. Benzoxazole derivatives (DS-1 to DS-8) shown significant activity as compared to Griseofulvin standard drugs.

Keywords: Antimicrobial activity, Antifungal activity, Benzoxazole.


[Full Text Article]

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