Abstract

SYNTHESIS, CHARACTERIZATION AND MICROBIAL ACTIVITY OF SOME NEW HETEROCYCLIC COMPOUNDS CONTAINING 4- THIAZOLIDINONE DERIVATIVES

Dr. Mayank S. Patel*, Dr. Divyanshu D. Patel, Dr. Vivek S. Patel, Prof. K. C. Patel, Prof. P. S. Patel

ABSTRACT

A series of new 4-thiazolidinone derivatives have been synthesised by condensing 4,4’-methylene bis N- substituted benzylidine-2-methyl aniline with thioglycolic acid in presence of anh. ZnCl2 in 1,4-dioxane. All of the synthesised compounds have been confirmed by elemental analysis, IR and 1H NMR spectral data. All the synthesised compounds (Ma–Mj) were screened for their antimicrobial properties against two Gram positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and three strains of fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using broth micro dilution method.

Keywords: 4,4’-methylene bis N- substituted benzylidine-2-methyl aniline,1,4-dioxane, anh. ZnCl2, thioglycolic acid, Schiff bases.