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  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

FORMULATION AND EVALUATION OF ACECLOFENAC ORODISPERSIBLE TABLETS USING NATURAL DISINTEGRANT

*Harish R. Lukkad1, Pravin K. Bhoyar2, Jagdish R. Baheti1, Nitin D. Somnathe3, Dhanashri B. Nagulwar4 , Prasad P. Kathade2

1Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India
2Siddhivinayak College of Pharmacy,Warora, Dist-Chandrapur, Maharashtra, India.
3Department of Pharmacy, Wadhawani College of Pharmacy, Yavatmal, Maharashtra, India.
4Department of Pharmaceutics, Sharad Pawar College of Pharmacy, Dist: Nagpur, Maharashtra, India.

ABSTRACT

Fast dissolving tablets are dissolved/disintegrate without water within few second to few minutes. Aceclofenac, a non-steroid anti inflammatory drug used for pain and inflammation and was selected as the model drug. Dispersible tablets of aceclofenac were prepared using natural substance mango peel pectin(MPP) as disintegrant in different concentration and also prepared using standard superdisintegrant crospovidone(CPD) by direct compression technique. The prepared powder blend was evaluated for various parameters like bulk density, tapped density, angle of repose, compressibility index and Hausner ratio. Formulations of MPP were evaluated for hardness, friability, wetting time, disintegration time, In vitro dissolution study and were compared with CPD. The study reveals that MPP can not be used as promising superdisintegrant, but due to its good solubility in biological fluid and better swelling index, it can be used to prepare fast dispersible tablets.

Keywords: Aceclofenac, Mango peel pectin, Crospovidone, Direct compression technique.


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