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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

SYNTHESIS OF NOVEL 2-AMINO-5,7-DIMETHYL-8-[1,8] NAPHTHYRIDINE-2-YL-4-ARYL-QUINOLINE-3-CARBONITRILES Via ONE-POT CONDENSATION

Ramu Kakkerla, Narendar Atmakuri & Namratha Vaddiraju*

* Department of Chemistry, University College of Science, Satavahana University, Karimnagar-505001(A.P.) INDIA.

ABSTRACT

A series of 2-Amino-5,7-dimethyl-8-[1,8]naphthyridin-2-yl-4-Arylquinoline- 3-carbonitriles (3a-i) has been synthesized by multicomponent reaction via one-pot conden sation of various aryl aldehydes, 3,5-dimethyl-2-[1,8]naphthyridin-2-yl-phenylamine and malononitrile in the presence of p-dimethylaminopyridine (DMAP, 10 mol %) as a catalyst in Ethanol with good yields.

Keywords: 3,5-Dimethyl-2-[1,8]naphthyridin-2-yl-phenylamine and 2-Amino-5,7-dimethyl-8-[1,8]naphthy ridin-2-yl-4-Aryl-quinoline-3- carbonitriles, Malononitrile and DMAP.

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