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Abstract

SYNTHESIS OF NOVEL 2-AMINO-5,7-DIMETHYL-8-[1,8] NAPHTHYRIDINE-2-YL-4-ARYL-QUINOLINE-3-CARBONITRILES Via ONE-POT CONDENSATION

Ramu Kakkerla, Narendar Atmakuri & Namratha Vaddiraju*

* Department of Chemistry, University College of Science, Satavahana University, Karimnagar-505001(A.P.) INDIA.

ABSTRACT

A series of 2-Amino-5,7-dimethyl-8-[1,8]naphthyridin-2-yl-4-Arylquinoline- 3-carbonitriles (3a-i) has been synthesized by multicomponent reaction via one-pot conden sation of various aryl aldehydes, 3,5-dimethyl-2-[1,8]naphthyridin-2-yl-phenylamine and malononitrile in the presence of p-dimethylaminopyridine (DMAP, 10 mol %) as a catalyst in Ethanol with good yields.

Keywords: 3,5-Dimethyl-2-[1,8]naphthyridin-2-yl-phenylamine and 2-Amino-5,7-dimethyl-8-[1,8]naphthy ridin-2-yl-4-Aryl-quinoline-3- carbonitriles, Malononitrile and DMAP.


[Full Text Article]

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