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Abstract

VALIDATED SIMPLE AND SENSITIVE UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF GLIBENCLAMIDE IN BULK AND PHARMACEUTICAL FORMULATIONS

Sidharth M. Patil 1*, Ramchandra N. Chilkawar1, Vinod Panchal2.

1, 2Department of Pharmaceutics, KLE’S College of Pharmacy, Nippani, Karnataka, India.

ABSTRACT

The present research work discussed the development of a UV spectophotometric method for estimation and validation of Glibenclamide. It is simple, fast, accurate and cost efficient and reproducible spectrophotometric method, developed for the estimation of Glibenclamide as a pure API. The wavelength (λ max) was found to be 230 nm by using ethanol and water in 1:5 ratio as a solvent for the Glibenclamide. The linearity for this drug at the selected wavelength lies between 2-14 μg/ml. Beer's law was obeyed in this concentration range with correlation coefficient of 0.995. The accuracy and precision of the method were determined and validated according to ICH guidelines. The method has good reproducibility with % RSD less than one. Thus proposed method can be successfully applied for Glibenclamide in routine analysis work.

Keywords: Glibenclamide, API, spectrophotometric method, ICH guidelines.


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