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Abstract

PHYTOCHEMICAL EVALUATION & PHARMACOLOGICAL SCREENING OF ETHANOLIC BARK EXTRACT OF DOLICHONDRONE FALCATA & ROOT EXTRACT OF SCROPHULARIA HYPERICIFOLIA FOR PSYCHOPHARMACOLOGICAL ACTIVITIES IN MICE.

Mehnoor Farheen*, Sumera Mahreen Khatoon, Asfia Kouser

ABSTRACT

Psychopharmacology is concerned with drug effects that modify the behaviour of animal organisms. This study assessed the antidepressant, antianxiety, antipsychotic, antiepileptic, hypnotic and sedative activities of ethanolic extract of Dolichondrone falcata and Scrophularia hypericifolia in diseases induced mice. Extraction of the ethanolic extract from bark of Dolichondrone falcata and roots of Scrophularia hypericifolia was performed by maceration. 24 mice were divided into six groups. Group I consisted of normal mice that were given only sterile saline solution and served as control group. Group II mice consisted of normal mice induced with disease either through drug or physically. Group III, IV, V consisted of normal mice induced with depression, anxiety, psychosis, epilepsy. Oral administration of extract resulted in significant antidepressant, antianxiety, antipsychotic, antiepileptic, hypnotic and sedative effect and muscle relaxant activity. Group VI consisted of normal mice induced with depression, anxiety, psychosis, epilepsy and were treated with standard drug. The effect produced by the extracts were closely similar to the standard drugs. In conclusion, the present study indicates that the ethanolic extract of Dolichondrone falcata and Scrophularia hyperictifolia appears to exhibit antidepressant, antianxiety, antipsychotic, antiepileptic, hypnotic and sedative activity, muscle relaxant activity in disease induced mice.

Keywords: elevated plus maze, forced swim test, haloperidol induced catalepsy, cerebral edema, neuronal degeneration.


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