PHYTOCHEMICAL EVALUATION AND PHARMACOLOGICAL SCREENING OF ETHANOLIC LEAF EXTRACTS OF EICHHORNIA CRASSIPES AND NELUMBO NUCIFERA FOR NEUROPHARMACOLOGICAL ACTIVITY IN PSYCHONEUROSIS INDUCED MICE
Mehnoor Farheen*, Syeda Arman R. O. Hussaini, Asfia kouser
ABSTRACT
Behavioral neuropharmacology focuses on the study of how drugs affect behavior in humans and animals. This study assessed the sedative, CNS depressant, Analgesic, Anti-epileptic, Anti-anxiety, Anti-psychosis, Anti depressant and Memory enhancing properties of ethanolic extract of Nelumbo nucifera, Eichhornia crassipes and combination of ethanolic extracts of Nelumbo nucifera and Eichhornia crassipes in disease induced mice. Extraction of ethanolic extract from leaves of Nelumbo nucifera and Eichhornia crassipes was performed by maceration. 24 mice were divided into six groups. Group I consisted of normal mice that were given only sterile saline solution and served as control group. Group II consisted of mice induced with depression, anxiety, psychosis, epilepsy and were treated with Normal saline. Group III, IV and V consisted of normal mice induced with depression, anxiety, psychosis, epilepsy. Oral administration of extract resulted in significant sedative, CNS depressant, Analgesic, Anti-epileptic, Anti-anxiety, Anti-psychosis, Anti depressant and Memory enhancing effects. Group VI consisted of normal mice induced with depression, anxiety, psychosis, epilepsy and were treated with standard drug. The effects produced by the extracts were closely similar to the standard drugs. In conclusion, the present study indicates that the ethanolic leaf extracts of Nelumbo nucifera and Eichhornia crassipes and combination of ethanolic extracts of Nelumbo nucifera and Eichhornia crassipes appears to exhibit sedative, CNS depressant, Analgesic, Anti-epileptic, Anti-anxiety, Anti-psychosis, Anti depressant and Memory enhancing activity in disease induced mice.
Keywords: Anti-psychosis, CNS Depressant, Depression, Eichhornia crassipes, Memory enhancing, Neuropharmacology.
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