Abstract

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF SALACIA FRUTICOSA

*Saravanan VS, Mohammed Ismail M, Manokaran S and Senthil SP

ABSTRACT

Salacia fruticosa belongs to family Hippocrateaceae has been traditionally used as remedy against diabetes mellitus, gastritis and inflammation. No scientific studies have been carried-out so far, in order to reveal the anti-inflammatory activity of Salacia fruticosa. The present study was aimed to investigate the anti inflammatory activity of ethanolic extract of salacia fruticosa by using carrageenan induced paw edema in albino rats at the dose of 200mg/kg body weight. The standard and control used for this study were diclofenac sodium (10mg/kg) and normal salaine (10ml/kg) respectively. The paw volumes of test, standard and control groups were measured at 60, 240,360 minutes of carrageenan treatment with the help of Digital Plethysmometer (Ugo basile, Italy). Mean increase in paw volume was measured and the percentage of inhibition was calculated.The extract showed significant anti-inflammatory activity as compared to standard.

Keywords: Salacia fruticosa, anti-inflammatory, carrageenan, diclofenac sodium.