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Abstract

DESIGN AND SYNTHESIS SERIES OF NOVEL QUINOLINYL METHANOL’S DERIVATIVES

Dawle Jairaj Kishanrao*, Puri Madhuri Kumara, Mathapati Sushil Ramakantb, omin Kalimoddin Inayatsabc , Bodage Abhay Shivajid

* aResearch Center of Pure & Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga.
bP. G. Research Center, Shri Madhavarao Patil Mahavidhyalaya, Murum.
cDept. Of Chemistry, Rajeshree Shahu. College Latur.
dDept. Of Chemisty, Shivneri College, Shirur Anantpal.

ABSTRACT

Functionalization of quinoline aldehydes, derived from isatin framework was carried out using Morita–Baylis–Hillman (MBH) chemistry. A number of novel quinoline-based diverse MBH adducts was prepared via the reaction of derivatives of 6-methoxy, 2-pheny, quinolinyl-4-carbaldehyde and various activated alkenes in good yields. Many of these compounds were found to be potent when tested against human prostate cancer (Pc-3). The prepared Quinolinyl derivatives were subjected to physicochemical studies like melting point determination, TLC and % yield. The structures of synthesized products were conformed through spectral study.

Keywords: Isatin, Quinoline aldehydes, Morita-Baylis-Hillman, Activated alkenes.


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