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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

FORMULATION AND EVALUATION OF STABLE ORAL FORMULATION OF BITTERLESS OFLOXACIN COMPLEXED WITH ION EXCHANGE RESIN

*Abhijeet Y. Patil1, Pravin K. Bhoyar2, Jagdish R. Baheti3, Satish M. Kardel3

1School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.
2Siddhivinayak College of Pharmacy,Warora, Dist-Chandrapur, Maharashtra, India.
3Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India.

ABSTRACT

Ofloxacin is an anti-infective drug used for the treatment of lower respiratory tract infections, skin infection, and urinary tract infections. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form. The purpose of present research work was to formulate tasteless complexes of ofloxacin with indion 234 ion exchange resin. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for taste masking and in vitro drug release. DSC analysis study give evidence of complex formation. Ofloxacin-Indion 234 complex of ratio 1:1.6% w/w was developed into suspension formulation using different suspending agents with different concentration and evaluated for sedimentation volume, pH, drug content and viscosity. The developed suspension is evaluated for taste masking. The results showed that ofloxacin was successfully taste masked and formulated into taste masked suspension formulation.

Keywords: Ofloxacin, Indion 234, Drug-resinate, Taste masking, Suspension.


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