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Abstract

EVALUATION OF RESPIRATORY PARAMETERS ASSOCIATED WITH PENH USING BAROMETRIC WHOLE-BODY PLETHYSMOGRAPHY

Anuradha Pannu, Ipshita Chattopadhyaya, Randhir Singh, Sumeet Gupta*

Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, Haryana-133203, India.

ABSTRACT

Background: Asthma is chronic, inflammatory disease of the airways affecting human beings worldwide. The aim of the present study was to evaluate the effect of anti-asthmatic drugs on Penh associated with the respiratory parameters using Barometric Whole-body Plethysmography. Material & Methods: The hannover rats (n=8) were divided into 6 groups for the study of Penh, Tidal & minute volume, inspiratory and expiratory flow rate. Theophylline and carbachol were administered orally and methacholine and clonidine in aerosol form. Results and discussion: Individualís respiratory parameters showed statistically significant (p<0.001) results except tidal volume. The Penh of carbachol and methacholine showed statistical variations in respiration at different time intervals. Conclusion:. Since there was movement of animals while doing these studies so Penh could not be justified for their results. Some more data will be needed in different conditions in future for the purpose of treating asthma.

Keywords: Asthma, Penh, Respiratory parameters, Whole-body plethysmography.


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