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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

EVALUATION OF RESPIRATORY PARAMETERS ASSOCIATED WITH PENH USING BAROMETRIC WHOLE-BODY PLETHYSMOGRAPHY

Anuradha Pannu, Ipshita Chattopadhyaya, Randhir Singh, Sumeet Gupta*

Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, Haryana-133203, India.

ABSTRACT

Background: Asthma is chronic, inflammatory disease of the airways affecting human beings worldwide. The aim of the present study was to evaluate the effect of anti-asthmatic drugs on Penh associated with the respiratory parameters using Barometric Whole-body Plethysmography. Material & Methods: The hannover rats (n=8) were divided into 6 groups for the study of Penh, Tidal & minute volume, inspiratory and expiratory flow rate. Theophylline and carbachol were administered orally and methacholine and clonidine in aerosol form. Results and discussion: Individual�s respiratory parameters showed statistically significant (p<0.001) results except tidal volume. The Penh of carbachol and methacholine showed statistical variations in respiration at different time intervals. Conclusion:. Since there was movement of animals while doing these studies so Penh could not be justified for their results. Some more data will be needed in different conditions in future for the purpose of treating asthma.

Keywords: Asthma, Penh, Respiratory parameters, Whole-body plethysmography.

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