Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

FORMULATION AND EVALUATION OF GASTRO RETENTIVE TABLETS OF ROSIGLITAZONE MALEATE

S. K. Yadav* Jaiswal V.K.

Department of pharmacy, university teaching department, Sarguja University Ambikapur, Chhattisgarh-497001.

ABSTRACT

The purpose of this research work was to develop gastroretentive drug delivery system for Rosiglitazone Maleate. Floating tablets were prepared by wet granulation method using gas generating agents such as sodium bicarbonate and tartaric acid, polymers like HPMC K100M and Guar gum. Formulations tried for different ratios and combination of HPMC K100M and Guar gum to get desired release profile. Prepared tablets were evaluated in terms of pre-compression and post-compression parameters. FTIR and DSC showed no interaction between drug and polymers. Rosiglitazone maleate floating tablets were prepared by wet granulation method were found to be good without chipping, capping and sticking. The drug content was uniform in all the tablet formulations indicating uniform distribution of drug within the matrices. All the prepared batches showed satisfactory floating lag time and total floating time found to be more than 12hr. Formulation F1, F2, F3, F4, F5 follows zero order, non fickian diffusion mechanism, it indicates release mechanism is both by diffusion and erosion. Higuchi confirms diffusion. Formulation F5 showed desired drug release selected as a best formulation and subjected to stability studies for 90 days showed that formulation is intact without interaction. Finally optimized formulation F5 complying with all the properties of floating tablets and found to be satisfactory.

Keywords: Gastro Retentive Drug Delivery System; Rosiglitazone Maleate; HPMCK100; Guar gum; wet granulation; Drug release kinetics.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More