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FORMULATION DEVELOPMENT AND EVALUATION OF BITTERLESS CHLORPHENIRAMINE MALEATE ORAL SUSPENSION*Abhijeet Y. Patil1, Pravin K. Bhoyar2, Jagdish R. Baheti3, Satish M. Kardel3
1School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India. 2Siddhivinayak College of Pharmacy,Warora, Dist-Chandrapur, Maharashtra, India. 3Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India.
ABSTRACT Chlorpheniramine maleate is an antihistaminic and antiallergic agent. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form. The purpose of present research work was to formulate tasteless complexes of chlorpheniramine maleate with indion 234 ion exchange resin. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for taste masking and in vitro drug release. DSC analysis study supported complex formation. Chlorpheniramine maleate -indion 234 complex of ratio 1:1.4% w/w was developed into suspension formulation using different suspending agents with varying concentration and was evaluated for sedimentation volume, pH, drug content and viscosity. The developed suspension is evaluated for taste masking. The results showed that chlorpheniramine maleate was successfully taste masked and formulated into suspension formulation. Keywords: Chlorpheniramine maleate, Indion 234, Drug-resinate complex, Taste masking, Suspension [Download Article] [Download Certifiate] |
