Abstract

FORMULATION OF EFFERVESCENT CIPROFLOXACIN HCl

Masaad A.M.A, Hamam Salih Badri* 
and Mohammed E. A. Shayoub

ABSTRACT

This research is a formulation of the drug as an effervescent tablet by two methods (direct compression and wet granulation). The bitter taste was masked by saccharine as sweeting agent furthermore the effervescent effect of citric acid, tartaric acid and sodium bicarbonate lead to improve the taste of the drug. Also the Guar was used as binder agent lead to hide the taste. [1] [2] The vanillin which was used as flavoring agent also enhances the palatability. [3] [4] The formulated tablets were passed all the fundamental testes in the monograph, and also microbiological sensitivity test was done against (Escherichia coli, Salmonella typhi, Salmonellapara typhi and Staphylococcus aureus ) and then the results were compared to select the suitable one. Also compression was done between two formula of wet granulation method (the binder increase concentration and die cavity when was change).This study was found that formulating the drug as effervescent tablet by wet granulation method (low bind er) concentration and die cavity No thirteen or twenty is the suitable.

Keywords: Taste masking, wet granulation, Effervescent ciprofloxacin HCL.