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Abstract

SYNTHESIS AND CHARACTERIZATION OF N 2 -SUBSTITUTED BENZENE SULFONYL N 1 - 5-SUBSTITUTED BENZOFURAN-2-CARBOHYDRAZIDE FOR THEIR ANTI-DIABETIC ACTIVITY

Dimple Pirgal*, Chandrashekar Javali, Pradeep Kumar R

ABSTRACT

The reaction of substituted benzofuran-2-carbohydrazide (1) with various substituted benzene sulfonyl chlorides (2) yielded corresponding N 2 -substituted benzene sulfonyl-N 1 -5-substituted benzofuran-2-carbohydrazides (3a-j). Elemental analysis, IR, H 1 NMR and mass spectral data confirmed the structure of newly synthesized compounds. The compound 3a, 3b, 3i and 3j were screened for their anti-diabetic activity in vivo using streptozotocin induced diabetic model. Derivative 3i and 3j were found to show significant hypoglycemic activity. Derivative 3b was found to be moderate active and the analogue 3a was found to be less potent as compared to other derivative.

Keywords: Benzofuran-2-Carbohydrazide/ Substituted Benzene Sulfonyl Chlorides/ Anti-Diabetic activity/Streptozotocin.


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