Abstract

INVESTIGATIONS ON EFFICIENCY OF CELEBREX AND VIOXX FOR RHEUMATOID ARTHRITIS THROUGH DOCKING

P. Rajasulochana* Syed Arfat

ABSTRACT

Rheumatoid Arthritis (RA) is a chronic, inflammatory, autoimmune disorder affecting the joints and sometimes other organs as well. It is by definition polyarticular; that is, it affects many joints. Scientists throughout the world are studying many promising areas of new treatment approaches for rheumatoid arthritis. The objective of this project is to uncover some of the aspects of Rheumatoid Arthritis, which will subsequently contribute to the ongoing research. Of all the drugs present for Rheumatoid Arthritis, we opted Celebrex and Vioxx which can be efficiently used for Rheumatoid Arthritis. The project work involves modification of the selected drugs. For this a deep rooted life study on these drugs was made. These modified drugs were compared with the existing one by comparing Log p value, molecular weight and by using Steepest and Polark algorithm. A QSAR study on the modified drugs were made which will be used for the treatment of the disease of interest.

Keywords: Rheumatoid arthritis, Chronic, QSAR, Polark algorithm.