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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NEW5, 6-DIAMINO-1, 3-DIMETHYLPYRIMIDINE-2, 4(1H, 3H)-DIONE DERIVATIVES

Vaijinath A. Verma*

ABSTRACT

A series of 5, 6-Diamino-1, 3-dimethylpyrimidine-2, 4(1H,3H)-dione derivatives were synthesized. An efficient synthesis of 5, 6-diamino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione bridge substituted to indole nucleus was described antioxidant of synthesized compounds (3 and 4) were determined by various in vitro assays such as 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH), Reducing ability by Fe3+ to Fe2+ method, Ferrous ion (Fe2+) chelating activities. Antimicrobial activity was carried out by cup plate method. These results were compared with the respective standards. Compounds 3a and 4a showed good radical scavenging activity (RSA). Compounds 3b, 4b and 4c exhibited good reducing power activity, whereas, the compound 3a, exhibited good metal chelating activity. Among the all compounds 4a exhibited promising antibacterial, antifungal activities.

Keywords: Pyrimidine, Indole, Antibacterial, Antifungal, Antioxidant activity.


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