Abstract

PHARMACOGENOMICS: ENABLING PERSONALIZED MEDICINE THROUGH PRECISION DRUG THERAPY OPTIMIZATION

Mohini Mishra*, Shubham Chavan, Vaikhari Kirkire, Kajal Gupta

ABSTRACT

Variability in medicine response among individualities remains a major challenge in ultramodern rectifiers. Conventional dosing rules are generally grounded on average responses from clinical trials and frequently fail to regard for natural differences among cases. Pharmacogenomics studies how inheritable variations impact medicine metabolism, efficacy, and safety, furnishing a scientific base for personalized remedy. Variants in genes garbling medicine- metabolizing enzymes, transporters, and receptors, similar as CYP2D6, CYP2C19, and VKORC1, can significantly alter remedial issues and the threat of adverse medicine responses. Advances in genomic technologies, particularly Next Generation Sequencing(NGS), have enabled the identification of multitudinous inheritable variants associated with medicine response. still, the large volume of genomic data generated requires advanced computational tools for effective interpretation. Artificial Intelligence(AI) and machine learning can dissect complex genomic and clinical datasets to prognosticate medicine responses, optimize dosing, and support clinical decision timber. The integration of AI with pharmacogenomics is advancing individualized drug and perfecting treatment safety and effectiveness.

Keywords: Pharmacogenomics, Personalized Medicine, Precision Drug Therapy, Artificial Intelligence, Next-Generation Sequencing (NGS)