Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

ENHANCING SOLUBILITY AND DISSOLUTION OF NAPROXEN BY SPRAY DRYING TECHNIQUE

Mudit Dixit*, Parthasarthi Keshavarao Kulkarni and R Narayana Charyulu

ABSTRACT

The aim of the present study was to improve the solubility and dissolution rate of Naproxen by preparing crystals by spray drying technique using Isopropyl alcohol (IPA) solvent. Naproxen crystals were produced by spray drying using IPA as solvent to enhance solubility and dissolution rate. The prepared Crystals were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FT-IR, XRD and SEM. Dissolution profile of the prepared spray dried crystals was compared with its recrystallized and pure sample. Spray dried crystals exhibited decreased crystallinity. The solubility of spray dried crystals exhibited twofold increases than the commercial Naproxen and dissolution showed 59 % release in 60 min. Consequently, from the above result it can be concluded that spray dried technique is a useful technique to improve the solubility and dissolution of poor water soluble drug like Naproxen.

Keywords: Spray drying, crystals, Naproxen, Crystallinity, solubility, dissolution.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More