ENHANCING SOLUBILITY AND DISSOLUTION OF NAPROXEN BY SPRAY DRYING TECHNIQUE
Mudit Dixit*, Parthasarthi Keshavarao Kulkarni and R Narayana Charyulu
ABSTRACT
The aim of the present study was to improve the solubility and dissolution rate of Naproxen by preparing crystals by spray drying technique using Isopropyl alcohol (IPA) solvent. Naproxen crystals were produced by spray drying using IPA as solvent to enhance solubility and dissolution rate. The prepared Crystals were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FT-IR, XRD and SEM. Dissolution profile of the prepared spray dried crystals was compared with its recrystallized and pure sample. Spray dried crystals exhibited decreased crystallinity. The solubility of spray dried crystals exhibited twofold increases than the commercial Naproxen and dissolution showed 59 % release in 60 min. Consequently, from the above result it can be concluded that spray dried technique is a useful technique to improve the solubility
and dissolution of poor water soluble drug like Naproxen.
Keywords: Spray drying, crystals, Naproxen, Crystallinity, solubility, dissolution.
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