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Abstract

ANTIDIABETIC ACTIVITY OF BARK PART ETHANOLIC EXTRACT OF ALBIZIA LEBBECK LINN IN ALLOXAN INDUCED DIABETIC RAT.

Gurdeep Singh*, Naveen Sharma, A.K. Jain, Ashish Dixit

ABSTRACT

The current study was designed to investigate the hypoglycemic effect of ethanolic extract of Albizia lebbeck bark (EAL) in alloxan induced diabetic rats. The effect of extract was observed by checking the biochemical, physiological and histopathological parameters in diabetic rats. Diabetes was induced by administering alloxan monohydrate (150 mg/ Kg body weight; intraperitoneal). After the oral administration of ethanolic extract at doses of 100mg/kg, 200mg/kg & 400mg/kg body weight, blood glucose levels and body weights were monitored at specific interval. In our study, both Glibenclamide (10mg/kg) and EAL significantly decrease fasting blood glucose and increases the body weight in alloxan induced diabetic rats as comparable to the animals in diabetic control group. The present study shows significant antidiabetic activity of EAL as compared to standard drug Glibenclamide.

Keywords: Albizia lebbeck, alloxan, antidiabetic, Glibenclamide, EAL, intraperitoneal.


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