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Abstract

STUDY OF DIFFERENT EVALUATION PARAMETER IN SELECTION OF POLYMERS USED FOR FILM COATING

Dr. Mrs. P. H. Sharma*, Dr.Mrs. J. G.Avari

ABSTRACT

The application of coating to the surface of pharmaceutical dosage form especially tablets has been practised for over 150 years. Film coating are an integral part of the dosage form development process. Film coating systems are concentrated blend of polymers, plasticizers, pigments, opacifiers, glident etc. Polymer constitutes a major component of the film coating system. The objective of the present study is to evaluate the different parameters of polymer for its selection for the purpose of film coating of tablet, with respect to their physicochemical properties to prevent the cracking of film on storage. The cellulose acetate and cellulose acetate Phthalate were used for film coating and evaluated for physicochemical parameters such as colour, softening point, acid value, glass transition temperature, moisture absorption study, IR study and Thermo gravimetric analysis. The film of cellulose and cellulose acetate Phthalate were prepared by mercury substrate technique and evaluated for different parameter such as thickness, moisture absorption study, Water vapour transmission study. Due to the great increase in the number of polymeric materials developed in recent years, an examination of these polymer and their properties for application in pharmaceutical coating is required .Hence the present study gives the detail information regarding the evaluation parameters of polymer with to respect to its physicochemical properties and the effect of plasticizer on film forming properties of polymers, which helps and give a complete guideline for the selection of polymers for film coating of tablet.

Keywords: polymers, plasticizers, softening point, acid value, glass transition temperature.


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