Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2020 Issue has been successfully launched on 1 February 2020.

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Abstract

SIMPLE AND RAPID ISOCRATIC RP-HPLC METHOD TO DETERMINE LOVASTATIN AND NIACIN IN BULK AND PHARMACEUTICAL FORMULATION

G.Tuljarani*, N.Srinivas, B.Karuna Devi and G.Vimala

ABSTRACT

A simple specific, sensitive, precise and reproducible reverse phase high-performance liquid chromatography (RP-HPLC) method has been developed for simultaneous estimation of lovastatin and niacin. The determination was carried out by using Symmetry C8 (4.6×250 mm, 5μm) column with the mobile phase containing acetonitrile: phosphate buffer (pH4.0±0.5) in the ratio of 65:35 v/v. The optimized flow rate was 0.7 ml/min and the UV detection was carried out at 240 nm. The retention time of lovastatin and niacin were found to be 3.093 min and 6.196 min respectively. The method was found to be linear in the concentration range 2.0 -10 μg/ml and 25-125 μg/ml for lovastatin (LS) and niacin (NC) respectively. The method was validated as per ICH guidelines. The proposed method was successfully applied for the estimation of lovastatin and niacin in pharmaceutical dosage forms.

Keywords: RP-HPLC, Lovastatin, Niacin, Validation.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More