Abstract

FORMULATION AND EVALUATION OF THYMOLE BASE MEDICATED NAIL LAQCUER

Prof. Meghana Gore, Pratiksha Jadhav*, Kaustubh Kadam, Preeti Kale,
Nayan Kamadi, Aishwarya Kamble

ABSTRACT

Transungual drug delivery offers localized treatment for nail infections such as onychomycosis, but drug penetration through the nail plate is limited. To overcome this, a medicated nail lacquer containing Thymol was formulated using nitrocellulose as a film-forming polymer, dibutyl phthalate as a plasticizer, and thioglycolic acid as a permeation enhancer. The formulation showed good film properties, improved drug diffusion, and significant antifungal activity against Candida albicans. Hence, Thymol-based nail lacquer is a promising and effective approach for localized management of fungal nail infections with reduced systemic side effects.

Keywords: Transungual drug delivery, Medicated nail lacquer, Thymol, Onychomycosis, Antifungal activity, Candida albicans, Nail permeation, Nitrocellulose polymer, Localized therapy.