Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2020 Issue has been successfully launched on 1 February 2020.

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Abstract

MANNICH BASES OF 7-HYDROXY COUMARINS AND THEIR BIOLOGICAL ACTIVITY

Touseef Begum*, Tasneem Mohammed, Suroor A. Khan

ABSTRACT

A novel series of coumarin Mannich bases (II i-x) have been synthesized by reacting 7-hydroxy-4-methyl-2H-chromen-2-one (I) with various substituted secondary amines (II i-x) in presence of formaldehyde. The structures of the newly synthesized compounds were characterized by IR, 1H NMR, and MASS data. Title compounds were screened for acute anti-inflammatory activity using the carrageenan-induced rat paw edema assay model. Most active compounds were also tested for their ulcerogenic activity. Among the compounds tested, 7-hydroxy-8-{[(4-methylphenyl)amino]methyl}-4- methyl-2H-chromen-2-one (ii), 7-hydroxy-8-{[(4- methoxylphenyl)amino]methyl}-4-methyl-2H-chromen-2-one (ix) and 7-hydroxy-8-{[(2-bromo-4,6-dinitrophenyl)amino]methyl}-4-methyl-2H-chromen-2-one (x) showed 71.24 , 62.53% and 62.24% inhibition, respectively after 1hr as compared to the standard drug Indomethacin (54.62%). These potent compounds showed reduction in ulcer. However, Compounds IIii, IIix and IIx, would be good candidates for lead molecules for antiinflammatory activity with a larger margin of safety.

Keywords: Coumarins, Anti-inflammatory activity, Ulcerogenic activity, Mannich bases.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More