Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF INJECTION OF POORLY SOLUBLE DRUG (TINIDAZOLE) USING NOVEL APPLICATION OF MIXED SOLVENCY CONCEPT

Ashish Yadav*, Hemant Kurmi, Swati Saxena, Rekha Birle

ABSTRACT

The objective of present research is the explore the application of mixed solvency technique in the injection formulation of poorly soluble drug and to reduce concentration of individual solubilized (used for solubility enhancement) to minimize the toxic effect of solubilized. the mixed blends in which solubility of tinidazole was more than 1 mg/ml and have much difference in their compositions were selected, such selected mixed blends were FT-5,FT-8 and F-8. To develop 2 ml of aqueous tinidazole injection and constituted dry powder tinidazole injection, the amount of solubilizers and drug that will be administered through each mixed blend was determined. In this case, the solubility agent employed to give a desirable solubility for the poorly soluble drug may produce its own toxicity. However, if the same enhancement in the solubility can be achieved by mixing, five solubilizer (each in one fifth concentration) then the toxicity level of five solubilizer can be reduced by five fold. In case of synergistic effect in solubility due to mixing of, five solubilizer (in the fifth concentration). These formulation evaluate by UV-visible spectroscopy and IR –Spectroscopy.

Keywords: Solubilized, Injection, Mixed Solvency, Tinidazole, blenzed.