Abstract

FORMULATION AND IN VITRO EVALUATION OF BETA ELEMENE (PIPER BETEL) NIOSOMES IN CANCER CHEMOTHERAPY

Mamatha Duggirala*, Dr. P. Vasanthkumar, K. Karunakar, M. Kavitha, G. Keerthana, G. Muralidhar Reddy and B. Priyanka

ABSTRACT

Drug delivery systems are defined as formulations aim for transportation of a drug to the desired area of action within the body. The aim of the study was to investigate the feasibility of using Niosomes as a drug delivery system for Piper betle (Beta-Elemene) leaf Extract, Cisplatin By entrapment of drug in Niosomes, dose also could be reduced. Niosomes were prepared by Ethanol injection method using cholesterol and Surfactant. Particle size, zeta potential, entrapment efficiency and in vitro drug release studies were performed. The targeted niosome delivery system is composed of drug, surfactant and cholesterol. With regard to the influence of formulation variables on the percent drug loading (PDL), different compositions with varying ratios of surfactant and cholesterol were studied. In –Vitro drug release mechanism was studied for 24 hours. Betel leaf extracts were a popular ingredient in food preparation in ancient times. The leaves were used to add flavor and aroma to dishes, as well as to act as a preservative. The leaves contain a variety of compounds such as alkaloids, flavonoids, tannins, and saponins, all of which contribute to the flavor and aroma of the food. Betel leaves and their constituent parts have been utilised for centuries for their medicinal benefits in treating wounds, indigestion, bad breath, inflammations, and inflammatory disorders. A wide variety of bioactive substances from betel leaf extracts and essential oil (EO), such as polyphenols and terpenes, have been found. The bioactive phenolic compounds in betel leaf make it a significant medicinal herb.

Keywords: Niosomes, Piper Betel (Beta-Elemene) leaf Extract, Cisplatin, Surfactants, Cholesterol, Ethanol Injection Method, In Vitro Release, Span & tween.