Abstract

THE EMERGING ROLE OF THIAZOLIDINONE IN MEDICINAL CHEMISTRY: A REVIEW OF RECENT DEVELOPMENTS (2018-2024)

Raj Kumar Singh*, Mr. Shourya Pratap, Dr. Amresh Gupta

ABSTRACT

Thiazolidinones, which have a wide range of biological functions, have become a promising scaffold in medicinal chemistry. A thorough summary of the most current advancements in the field of thiazolidinone-based medicinal chemistry from 2018 to 2024 is what this review attempts to deliver. In order to emphasise the prospective uses of thiazolidinone derivatives as antibacterial, antiviral, anti-inflammatory, anticancer, and neuroprotective medicines, we go over their synthesis, structural changes, and biological assessments. The review also looks at the pharmacokinetic characteristics, molecular docking studies, and structure-activity connections of drugs based on thiazolidinone. We also go over the difficulties and prospects for thiazolidinone-based drug discovery, highlighting the necessity of more study to completely realise the therapeutic potential of this adaptable scaffold. This review highlights the potential of thiazolidinone-based medicinal chemistry to aid in the creation of new therapeutic medicines while offering a timely update on the field's current status.

Keywords: thiazolidinones, antibacterial agents, molecular modeling, docking studies, structure-activity relationship.