Abstract

FORMULATION AND DEVELOPMENT OF GASTRORETENTIVE FLOATING TABLET OF CLINDAMYCIN USING NATURAL POLYMER

Hatim Millwala*, Dr. Nidhi Bais, Dr. Sachin K. Jain and Dr. Sudha Vengrulekar

ABSTRACT

Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms as well as topically for acne vulgaris. . It was formulated as a floating tablet using different polymer like synthetic and natural polymer HPMC K4M, Tara Gum and use of tartaric acid & sodium bicarbonate as a gas generating agent & Carbopol 940 as a film former in a combination of suitable excipients. It is easy for the administration to afford and decreased frequency of administration resulting he better patient compliance and acceptance. Therefore, thought worthwhile to develop an oral dosage form, floating tablet using a suitable polymer to effectively deliver the drug with sustained and prolonged release and the drug before itreaches the absorption window enhanced drug bioavailability and due to combined polymer of natural & synthetic it reduce the side effect which is found in marketed preparation of tablet, like confusion, constipation, vomiting. It is observed from formulation F6 which shows a better effect than other batches. Thus, it can be concluded that the drug given in the form of floating tablet provides better patient compliance and an effective mode of treatment.

Keywords: Clindamycin, acne vulgaris, floating tablet Carbopol 940, patient compliance.