Abstract

FORMULATION AND EVALUATION OF ORAL DISSOLVING FILM OF RIZATRIPTAN BENZOATE FOR GERIATRIC AND PAEDIATRIC PATIENTS

Rahul Padalkar*, Vaibhav Kapgate and Ashwini Madgulkar

ABSTRACT

This work was aimed to develop orally dissolving films (ODF) of rizatriptan. Rizatriptan is 5HT1 receptors agonist used to treat migraine pain where faster onset of action is desirable. ODF were prepared using solvent casting method incorporating pullulan and propylene glycol. A 32 full factorial design was used for formulation development and optimization. The formulation approach was oriented towards achieving faster disintegration with good mechanical strength. It was observed that these characteristics were directly affected by the film former and plasticizer contents. Developed mathematical models were found to be statistically significant as well as practically valid for predicting the values of response variables within the design space. The optimized formulation contained 3.48% of pullulan and 3% of propylene glycol that showed disintegration within 41 seconds and 4.15 N/mm2 of tensile strength.

Keywords: Rizatriptan benzoate, Oral dissolving films, Migraine.