Abstract

EFFECT OF NATURAL AND SYNTHETIC POLYMER ON DRUG RELEASE PROFILE OF IBUPROFEN TABLETS- PHYSICOCHEMICAL PROPERTIES, ANALYSIS OF KINETICS AND FIT FACTOR

Pratiksha N. Kolekar* and Anuradha K. Salunkhe

ABSTRACT

In pharmaceutical formulations, natural gums and mucilage are currently being used as important medication excipients more and more. The cost-effective, risk-free, biocompatible, and biodegradable natural materials manufactured of plants. Ibuprofen matrix tablets were produced utilising HPMC (K100M), a synthetic polymer, and Aloe Vera leaf mucilage, a natural polymer, in order to preserve drug release from the matrix system. There were a total of six batches produced (F1–F6). Direct compression was used to make sustained-release matrix tablets. The physical properties of the tablets, such as weight fluctuation, thickness, diameter, hardness, friability, and in vitro drug release, were evaluated by IP. Concurrently, investigations into the differences between man-made and natural polymers were carried out. The swelling properties and drug release times of the formulations were studied for up to 12 hours. The results showed that as the
proportion of mucus increased, the total drug release time from the matrix tablet also increased. According to a dissolution study, dried Aloe Vera mucilage can be used as an excipient in the production of sustained release tablets. The drug release rates of both natural and synthetic polymers were slowed down by increasing the polymer concentration. The formulation with the highest absorption rate was batch F3, which had 16 mg of Aloe Vera mucilage and showed a dissolution profile of 95.81% over a 12-hour period, comparable to batch F6's dissolution profile of 98.08%.

Keywords: Aloe Vera Mucus, Direct Compression, HPMC, Ibuprofen, Sustained Release Tablet, and Matrix Tablet are some examples of the Aloe Vera mucus products.