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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

POPULATION PHARMACOKINETICS OF METHOTREXATE IN RHEUMATOID ARTHRITIS PATIENTS IF SOUTH INDIA

Dr. Anand Viyakumar P. R.*, Ranjith S. P., Devadharshini D., Sarvesh Nikesh R., Deepakkumar M., Kaviya R., Harshini M.

ABSTRACT

This study examines the population pharmacokinetics of Methotrexate, a widely used medication for Rheumatoid Arthritis. Rheumatoid Arthritis is a persistent autoimmune disease affecting small joints due to immune system mismanagement. Population Pharmacokinetics (PPK) aims to measure variability in drug absorption, distribution, metabolism, and elimination among individuals. The research, carried out over 10 months, involves 25 adult patients, investigating factors like age, weight, and dose response. Ethical considerations adhere to the Helsinki Declaration, highlighting informed consent. Methotrexate concentrations are analysed through a two-compartment open model. Findings reveal impacts of age on drug clearance and body weight on volume distribution. The research underscores the importance of population pharmacokinetics in customizing drug dosages for individual patients, providing valuable insights for clinical applications.

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