Abstract

BIORELEVANT MEDIA – AN APPROACH TO ALTER THE DRUG RESPONSE

Sowmya Devarakonda, Venu Madhav Katla* and Somnath De

ABSTRACT

Biorelevant media serve as laboratory test solutions that replicate the composition and qualities of gastrointestinal fluids during both fasting and fed states. This makes them a suitable surrogate for in vivo performance in vitro. These solutions replicate the physiological components of actual fluids, including bile secretion, salts, and pH. Through simple in vitro biorelevant experiments, developers can assess the discriminatory properties of these media and analyze the dissolution characteristics of poorly water-soluble drug formulations over time. Over the past decade, biorelevant media have proven successful in establishing in vitro-in vivo correlations, predicting oral drug absorption, and forecasting the impact of formulations and food on drug release as well as tablet or capsule disintegration. In contrast to traditional artificial surfactant test media like SLS, biorelevant media accurately mirror physiological conditions by incorporating natural
surfactants such as bile salts and lecithin found in the small intestine. These elements significantly influence drug absorption. Utilizing more precise media in drug testing can result in more accurate outcomes. This article aims to provide information on the composition of biorelevant dissolution media, highlighting their superior accuracy in predicting in vivo performance compared to standard compendia dissolution media.

Keywords: Biorelevant media, Simulation, Dissolution, Invitro studies and In vivo studies.