Abstract

HENOCH-SCHONLEIN PURPURA: A COMPREHENSIVE OVERVIEW OF THIS AUTOIMMUNE DISORDER

Dr. Sneha Gupta*

ABSTRACT

Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Pathologically, it can be considered a form of leukocytoclastic vasculitis that can involve not only the skin but other tissues as well. Though it primarily affects children (over 90% of cases), the occurrence in adults has been rarely reported (3.4 to 14.3 cases per million). This low incidence could be due to either under-diagnosis or misdiagnosis.

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