Abstract

DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF THE PROLIPOSOME CONTAINING GLIMEPIRIDE

Muskan Gupta*, Ashish Kumar Chaurasia, Umesh Kumar Chaurasiya and Sanjay Jain

ABSTRACT

The typical biphasic release pattern for proliposome formulations was first a fast burst release lasting for two hours, followed by a steady release lasting for twenty-four hours. Both the significant concentration gradient seen at the earliest time points and the speedier release of unentrapped drug from the proliposome formulations may have contributed to the rapid drug release. Glimepiride displayed good solubility in methanol. But it remains insoluble in water and buffer solution. Proliposomes are cutting-edge drug delivery systems that can help medications with low oral bioavailability penetrate the body more effectively and be more readily absorbed. Several phospholipids with variable acyl chain lengths, levels of saturation, and bilayer fluidity were examined for creating proliposomal formulations in order to study the impact of phospholipid composition on the physicochemical
characteristics of liposomes.

Keywords: Liposome, Proliposome (PL), Glimepiride.